DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 20, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: Unpublished P.I. NAMES: Robley Evans INSTITUTION: MIT CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: Radium & Mesothorium Poisoning and Dosimetry and Instrumentation Techniques in Applied Radioactivity SUBJECTS: (Expanded after trial run) Total: 20 Male: Fem: X Sex not given Type: Civilian Minor (under 18) X Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: The Age Center of New England Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: "Metabolism and Biological Effects of Pu, Po, Rm, Th, U, and Pb 212" Date of Research: 1961-1965 Publication(s): Funding Institution(s): Gov't Application: Grant/Contr.#: MIT-952-1 name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) radiation research (no benefit to subject; uncertain risk) external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment X scientific (no benefit to subject) X metabolism (tracers) dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Radium 224, Thorium 234 Administration: X ingestion inhalation injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Shields Warren, John Bugher, Charles Durham, John Totter. The report is MIT Annual Progress Report Contract AT (33-1)-952 Other Institutions Named: Other experiments names: Additional Comments: It's a "gut" (gut uptake study) Lots of stipulation about the subject After ingestion, feces, urine & breath sampled They wee injected at MIT infirmary. After brought to radioactivity Center. Signed by C. Maletskoi, H. Anderson, A Brown, J. Byron, S. Clark, M. Costello, E. Dillon, J. Foley, J. Gary, A. Keane, J. Kelles, M. Lubin, H. Osborn, M. Shanahan, N. Tells. NIH Funding. Further reports MIT-952-2, MIT 95-3 May 1965 This was all follow-up to the radium watch-dial painters. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 20, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: Durbin INSTITUTION: CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: SUBJECTS: (Expanded after trial run) Total: Male: Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Date of Research: Publication(s): Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) radiation research (no benefit to subject; uncertain risk) external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) X unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: This study of 1972 looks at the scope of the original 18 subjects in the light of recent understanding of the biochemistry of Pu. She cites the studies of Langham, Russell and Mukson, Prowley, et al., Foreman et al. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 22, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: Griem INSTITUTION: ACRH CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: AT(11-1) 69, NSA 2:1385(1972) SUBJECTS: (Expanded after trial run) Total: Male: Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Chicago Lying-In Hospital Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: No How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: "Analysis of the Morbidity and Mortality of Children Irradiated in Fetal Life" Date of Research: 1945 Publication(s): Funding Institution(s): AEC Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) X radiation research (no benefit to subject; uncertain risk) X external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation injection skin-absorption External Irradiation: Dose: 15-3 rad 500 millirads on infant Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: Children/fetus Wow! This is an unbelievable study--irradiating fetus. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 22, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: P.V. Harper INSTITUTION: CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: AT(11-1) 69 SUBJECTS: (Expanded after trial run) Total: Male: Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Total-Body Radiation Facility Date of Research: 1968 Publication(s): Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) radiation research (no benefit to subject; uncertain risk) external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) X Other Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Totter Other Institutions Named: Other experiments names: Additional Comments: Simply a study of plutonium levels of people in various cardiac disease studies DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 22, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: C.A. Hawley INSTITUTION: INEL CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: SUBJECTS: (Expanded after trial run) Total: Male: Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Radioactive Milk Study Date of Research: 1963 Publication(s): Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) X radiation research (no benefit to subject; uncertain risk) external internal X intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: I-131 Administration: X ingestion X inhalation injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: This is the test which involved releasing I-131 on pasture land, having cows eat the grass, and then having human volunteers during the milk from the cows. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 22, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: R.J. Hasterback INSTITUTION: ACRH CO-RESEARCHERS NAME(S): B.G. Oppenheimer, M.L. Greim TITLE, DOC. ID# or NAME: SUBJECTS: (Expanded after trial run) Total: 400 Male: Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Long Range Effects of Internal Emitters Date of Research: 1950's through 1980's Publication(s): Finkel, Miller, Hasterback, "Radium Induced Malignant Tumors in Man" Delayed Effects of Bone-Seeking Radionuclides. Utah 1969 Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) X radiation research (no benefit to subject; uncertain risk) X external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation injection X skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: Follow-up study of many people exposed to radium in different ways. Study of Radium-exposed persons (including watch-dial painters) DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 20, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: Paul Heller INSTITUTION: Pacific NW Research Foundation and Univ. of WA CO-RESEARCHERS NAME(S): Mais Rowley, Alvin Paulsen TITLE, DOC. ID# or NAME: "Testicular Irradiation of Inmates at Oregon and Washington State Prison" SUBJECTS: (Expanded after trial run) Total: 67 Male: 67 Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) X Institutionalized: Federal X State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Oregon and Washington State Prison Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: "Effects of Radiation on the Human Testes" Date of Research: 1963-1975 Publication(s): Report: "Effects of Ionizing Radiation on the Testicular Function in Man" 1972 Funding Institution(s): Gov't Application: Grant/Contr.#: AEC/ERDA $1.62 Mil. name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) X radiation research (no benefit to subject; uncertain risk) X external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation injection skin-absorption External Irradiation: Dose: 100-600 rad Radiation Type: X x-ray beta alpha proton neutron other Administration: whole body hemi-body X localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: Prisoners at Oregon State Prison DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 20, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: Unpublished P.I. NAMES: Langham, Samuel Bennett INSTITUTION: CANL CO-RESEARCHERS NAME(S): Payne Harris, Robert Carter TITLE, DOC. ID# or NAME: Factsheet Human Experimentation #20, SFS 1.001 SUBJECTS: (Expanded after trial run) Total: Male: Fem: Sex not given Type: Civilian X Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: "A Study of Individual Variation of Excretion of Pu by Man" Date of Research: 1945 Publication(s): Funding Institution(s): AEC Gov't Application: Grant/Contr.#: LA-1151 name unknown immediate branch effects X occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Yes (6/14/79) Type of Research: (Experiment may fall into one or more type) radiation research (no benefit to subject; uncertain risk) external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment X scientific (no benefit to subject) metabolism (tracers) X dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Pu 239 Administration: ingestion inhalation X injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Stafford Warren (U.S. McCann, A.H. Dowdy, W.F. Bale, Harold Hodge, L.H. Hempelmann), planning Other Institutions Named: Other experiments names: Additional Comments: MED Contract WO740-Enj.49 AEC 7405-Enj-36 45 page report Hyman, Fredell, Fred Bryan, reps of Office of Medical Director J.G. Hamilton, Jack Schubert, E.R. Ronnell, Austin Brues, H.M. Decker contributed information Hempelmann, T.N. White, Frederick Reines, E.C. Anderson, J.T. Benna, G.W. Taylor reviewed the report Wished to check effect of Pu workers. Fecal and Urinary Analysis. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 22, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: P.I. NAMES: Margaret Nickson INSTITUTION: CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: CH-3833 SUBJECTS: (Expanded after trial run) Total: 15 Male: Fem: Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Effect of Single Dose X-ray to the Nail-Fold Area of Human Subjects Date of Research: Publication(s): Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological fallout effects/countermeasures Classified Initially?: Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) X radiation research (no benefit to subject; uncertain risk) X external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment scientific (no benefit to subject) metabolism (tracers) dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation injection skin-absorption External Irradiation: Dose: Radiation Type: X x-ray beta alpha proton neutron other Administration: whole body hemi-body X localized Other Individuals Named: Shields Warren -- Contact Other Institutions Named: Other experiments names: Additional Comments: Left 4th finger x-ray exposure. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 20, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: Unpublished P.I. NAMES: Robert S. Stone INSTITUTION: MED CO-RESEARCHERS NAME(S): TITLE, DOC. ID# or NAME: Fact Sheet Human Exp-01 (Markey) (page 1) SUBJECTS: (Expanded after trial run) Total: 18 Male: 5 Fem: 13 Sex not given Type: Civilian X X Minor (under 18) X Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Oak Ridge, Chicago, UCSF, Rochester Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Plutonium Excretion Studies Date of Research: 1945-1947 Publication(s): P. Durbin. "Pu in Man." 1972. Considered a whole experiment by Markey. Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological X fallout effects/countermeasures Classified Initially?: Yes Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) radiation research (no benefit to subject; uncertain risk) external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment X scientific (no benefit to subject) metabolism (tracers) X dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation X injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: I.G.'s Report published 1974. One of the "Markey" experiments studied by I.G. in 1974 See, "Raulard, R.G. and Durbin, P.W. "Sa whole experiment by Markey. Funding Institution(s): Gov't Application: Grant/Contr.#: name unknown immediate branch effects occupational radiological X fallout effects/countermeasures Classified Initially?: Yes Classified by Whom?: Declassified?: Type of Research: (Experiment may fall into one or more type) radiation research (no benefit to subject; uncertain risk) external internal intentional release follow-up of accidental exposure therapeutic/diagnostic (possible benefit to subject) experimental routine use in a non-radiation related experiment X scientific (no benefit to subject) metabolism (tracers) X dosimetry (biodistribution) unknown Internal Irradiation Dose: Isotope Used: Administration: ingestion inhalation X injection skin-absorption External Irradiation: Dose: Radiation Type: x-ray beta alpha proton neutron other Administration: whole body hemi-body localized Other Individuals Named: Other Institutions Named: Other experiments names: Additional Comments: I.G.'s Report published 1974. One of the "Markey" experiments studied by I.G. in 1974 See, "Raulard, R.G. and Durbin, P.W. "Survival, Causes of Death, and estimated Tissue Doses in a Group of Human Beings Injected with Pu." The Health Effects of Radium. Webster S.S. ed. 1976 Life expectancy less than 18 years Unpublished reports: Russell, E.D. Nicholson, J.S. "Distribution and Excretion of Pu". Industrial Medicine on the Plutonium Project. (E.S. Stone. Ed.) National Nuclear Energy Studies, Division IV, Vol. 20. McGraw-Hill 1951. Robertson, J.S. and Cohn, S.H. "Evaluation of Pu Exposure in Man." Health Physics. 10:373-389. DATA ENTRY FORM: EXPERIMENT OF INTEREST FORM COMPLETED BY: Engel ON: June 20, 1994 TYPE OF INCIDENT: Experiment SOURCE TYPE: Unpublished P.I. NAMES: N. Silberstein INSTITUTION: Rochester, LANL, Oak Ridge, Mass. General CO-RESEARCHERS NAME(S): J. Hursa, W. Sweet TITLE, DOC. ID# or NAME: SUBJECTS: (Expanded after trial run) Total: 4 Male: Fem: X Sex not given Type: Civilian Minor (under 18) Over 65 Patient, non-terminal Patient, terminal (Hospital) Institutionalized: Federal State Local (Name:) Military (Service:) Employee of sponsor (Name of employer:) Institutional Link: Rochester, LANL, Oak Ridge, Mass. General Protocol/Consent (Added after trial run) Protocol available?: Where?: Consent reportedly given?: How?: Is consent form available?: Where?: Information given available?: Where?: Other Evidence of Consent: Where?: Title of Research: Date of Research: 1947, 1953-54, 1965, 1967 Publication(s): Funding Institution(s): Gov't Ap